I cannot say that there has been much of an improvement with me since the entry from a week ago. It's been a week dealing with the med changes. So, one week with only 3 medications. The two we removed are officially out of my system at this point I guess. As for the one we are increasing, the 50 mg increase has been a week now and will go for another week. Then, we bump it another 50 mg. I do not hold out hope. I've learned not to do that.